A scientist-led NGS library preparation service. You decide how much of the protocol is fixed and how much is yours to shape — from validated standard workflows to fully custom method development. The scientist who scopes your project is the one who runs it at the bench.
Tell us about your projectMost providers hand you a fixed menu. We hand you a control. Every project sits somewhere on a single spectrum — defined to custom — and gets scoped from there. If you're not sure where yours fits, that's a conversation, not a guess.
Validated, predetermined protocols with predictable scope. The right choice for routine WGS, RNA-seq, or methylation done correctly and quickly — no one reinventing a workflow that already works.
Input type and mass, fragmentation, amplification, cleanups, normalization, QC depth — all open. The prep itself becomes part of the experiment, designed and documented with you.
Each can be run anywhere on the dial. Every workflow starts with a real conversation before your samples ship, and gives you direct access to the scientist doing the work.
PCR-free and amplified library preparation across a wide range of DNA inputs and quality levels — including samples other providers flag as insufficient or risky.
Total RNA-seq and mRNA-seq. We work out the right approach with you before anything ships — ribosomal depletion versus poly-A enrichment, handling for degraded or low-input material, the biological question driving the design.
TAPS+ chemistry — simultaneous detection of 5-methylcytosine and genetic variants from a single library. Non-destructive conversion preserves four-base complexity for superior alignment, higher CpG coverage, and fewer false positives than bisulfite-based approaches.
Every project follows the same standard regardless of size or where it sits on the dial.
We align on your goals, review your sample types and sequencing requirements, and identify risk areas before anything moves.
Every sample is QC'd on arrival. Concentration, quality metrics, assumptions, and flags — documented before we touch a reagent.
Prepared by an experienced scientist using protocols set to your point on the dial — focused, attentive execution.
Before committing sequencing dollars, you see every library metric. We review together and make an explicit decision — no surprises downstream.
We pool, QC, and deliver your libraries to our local sequencing partners. One invoice, one point of contact.
A single report pulling together every stage of the project — preflight, library QC, pooling, and sequencing hand-off — into one organized document you can keep and share.
We scope each project individually. The more you can tell us up front, the more useful our first response will be — if you're not sure about something, leave it blank.
Typical response time: one business day.
Anneal Bio was founded by an NGS scientist with twelve years of hands-on experience across the Cambridge and Greater Boston biotech corridor — including Labcorp and Exact Sciences. The background spans library preparation, high-throughput automation, workflow validation, and quality control across development, production, and clinical-adjacent environments. The idea behind Anneal Bio is simple: give a lab the kind of NGS specialist it would hire if it had the headcount — without the headcount.